Robert R. Fenichel

Receptor Binding

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Drug Class Model Receptor IC50 (µM) Relative Potency (IKr/X) Ref Comment
alfuzosin alpha1-blocker HERG/CHO IKr 83.3 --- 92
almokalant antiarrhythmic rabbit VM IKr 0.005 --- 38
amiodarone antiarrhythmic rat VM ICaL 5.8
93
amiodarone antiarrhythmic rabbit VM IK1 50
29
amiodarone antiarrhythmic guinea-pig AM IKAch 2
24
amiodarone antiarrhythmic guinea-pig VM IKNa 1
23
amiodarone antiarrhythmic AT-1 IKr 0.7 --- 129
amiodarone antiarrhythmic AT-1 IKr 1 --- 130
amiodarone antiarrhythmic HERG/L IKr 1 --- 130
amiodarone antiarrhythmic rabbit VM IKr 2.8 --- 64
amiodarone antiarrhythmic rabbit VM IKr 10 --- 21
amiodarone antiarrhythmic HERG/XO IKr 10 --- 73
amiodarone antiarrhythmic rat VM Ito 4.9
22
amiodarone antiarrhythmic rabbit VM Ito >10
21
amitriptyline antidepressant HERG/CHO IKr >3 --- 112
amitriptyline antidepressant HERG/CHO IKr 10 --- 114
amitriptyline antidepressant rat neuron IKr 10 --- 125
amlodipine dihydropyridine AT-1 IKr 1 --- 130
amlodipine dihydropyridine AT-1 IKr 3
129
aprinidine antiarrhythmic HERG/COS IKr 0.23 --- 59
aprinidine antiarrhythmic COS IKs >10
59
astemizole antihistamine GP cerebellum H1 0.052 58 27
astemizole antihistamine GP LM H1 0.079 88 74
astemizole antihistamine GP LM H1 0.3 333 63
astemizole antihistamine guinea-pig VM IK1 >10
31
astemizole antihistamine HERG/HEK IKr 0.0009 --- 138
astemizole antihistamine guinea-pig VM IKr 0.0015 --- 101
astemizole antihistamine HERG/HEK IKr 0.022 --- 46 at 37°C
astemizole antihistamine HERG/XO IKr 0.048 --- 110
astemizole antihistamine HERG/XO IKr 0.069 --- 40
astemizole antihistamine HERG/XO IKr 0.33 --- 111
astemizole antihistamine
IKs >10
101 10uM = IC0.3
astemizole antihistamine XO IKs >60
110
astemizole antihistamine XO IKv1.1 >60
110
astemizole antihistamine XO IRK1 >60
110
astemizole antihistamine guinea-pig VM Ito >10
31
astemizole antihistamine
Ito >10
30 10uM = IC23
desmethylastemizole antihistamine GP LM H1 0.2 10 63
desmethylastemizole antihistamine HERG/HEK IKr 0.001 --- 138
norastemizole antihistamine HERG/HEK IKr 0.028 --- 138
atropine anticholinergic
IKr 0.558 --- 76
azimilide antiarrhythmic GP VM ICaL >10
54
azimilide antiarrhythmic GP VM IK1 >10
54
azimilide antiarrhythmic GP VM IKr 0.4 --- 54
azimilide antiarrhythmic HERG/XO IKr 1.4 --- 34
azimilide antiarrhythmic GP VM IKs 3
54
bepridil antianginal guinea-pig VM ICaL 0.5
134
bepridil antianginal guinea-pig AM ICaL 1.55
57
bepridil antianginal sheep PF IK1 >1.8
28
bepridil antianginal HERG/COS IKr 0.55 --- 42
bepridil antianginal IKs/COS IKs 10
42
bepridil antianginal guinea-pig AM INa 4.43
57
bepridil antianginal guinea-pig VM INa 30
134
bepridil antianginal sheep PF Ito <30
28
buprenorphine opiate HERG/HEK IKr 7.5 --- 71
captopril ACE inhibitor AT-1 IKr 10 --- 129
carvedilol beta-blocker HERG/XO IKr 10.42 --- 69
cetirizine antihistamine GP cerebellum H1 0.47 0.004 27
cetirizine antihistamine rabbit VM IK1 >1000
37
cetirizine antihistamine HERG/XO IKr >30 --- 111
cetirizine antihistamine rabbit VM IKr 108 --- 37
cetirizine antihistamine rabbit VM IKs >1000
37 1mM = IC44
chlorpheniramine antihistamine GP LM H1 0.002 0.001 74
chlorpheniramine antihistamine
IK1 >10
101 10uM=IC0.6
chlorpheniramine antihistamine
IKr 1.1 --- 101
chlorpheniramine antihistamine GP VM IKr 1.6 --- 102
chlorpheniramine antihistamine HERG/XO IKr 21 --- 110
chlorpheniramine antihistamine
IKs >10
101 10uM = IC9.7
chlorpromazine antipsychotic HERG/CHO IKr 1.47 --- 114
ciprofloxacin antibiotic/quinolone HERG/CHO IKr >100 --- 33 -40 mV
ciprofloxacin antibiotic/quinolone HERG/CHO IKr 966 --- 66
cisapride prokinetic various 5HT4 0.023-0.031 0.5 89
cisapride prokinetic HERG/HEK IKr 0.0065 --- 91 different lab
cisapride prokinetic rabbit VM IKr 0.009 --- 36
cisapride prokinetic guinea-pig VM IKr 0.015 --- 48
cisapride prokinetic HERG/CHO IKr 0.016 --- 123 at 20-22°C
cisapride prokinetic HERG/CHO IKr 0.024 --- 123 at 37°C
cisapride prokinetic HERG/HEK IKr 0.044 --- 95
cisapride prokinetic HERG IKr 0.044 --- 76 at 32-37°C
cisapride prokinetic
IKs 3.39
76 at 32-37°C
cisapride prokinetic guinea-pig VM IKs >10
48
cisapride prokinetic
IKv1.5 21.2
76 at 32-37°C
cisapride prokinetic
Ito 9.33
76 at 32-37°C
clarithromycin antibiotic/macrolide HERG/CHO IKr 20 --- 2 +MiRP1
clarithromycin antibiotic/macrolide HERG/CHO IKr 59 --- 2 WT
clobutinol antitussive
IKr 2.9 --- 26
clofilium antiarrhythmic AT-1 IKr 1.25 --- 32
clotrimazole antifungal GP VM ICaL <25
113 5=IC16, 25 = IC59
clozapine antipsychotic human AM IK1 >100
46
clozapine antipsychotic HERG/HEK IKr 0.191 --- 46 at 37°C
clozapine antipsychotic human AM INa 29.0
46
clozapine antipsychotic human AM Isus >100
46
clozapine antipsychotic human AM Ito 50-100
46
cocaine local anesthetic HERG/HEK IKr 7.2 --- 135
codeine opiate HERG/HEK IKr > 300 --- 71
cromakalim chromanol deriv GP VM IKr >20 --- 58
cromakalim chromanol deriv IKs/COS IKs >10
85
cromakalim chromanol deriv GP VM IKs >20
58
cyproheptadine antihistamine GP cerebellum H1 0.003
27
diltiazem calcium antagonist HERG/COS IKr >10 --- 42
diltiazem calcium antagonist HERG/HEK IKr 17.3 --- 136
diltiazem calcium antagonist IKs/COS IKs >10
42
diphenhydramine antihistamine GP LM H1 0.042 0.038 74
diphenhydramine antihistamine GP VM IKr 0.03 --- 72
diphenhydramine antihistamine GP VM IKr 1.1 --- 102
diphenhydramine antihistamine HERG/XO IKr 27 --- 110
disopyramide antiarrhythmic rabbit VM IKr 1.8 --- 120
disopyramide antiarrhythmic AT-1 IKr 58 --- 98
disopyramide antiarrhythmic AT-1 IKr 60-100 --- 130
disopyramide antiarrhythmic HERG/L IKr 92
129
disopyramide antiarrhythmic
INa 28
132
disopyramide antiarrhythmic rabbit VM Ito 14
120
dofetilide antiarrhythmic GP VM IK1 >1
61
dofetilide antiarrhythmic rabbit VM IKr 0.0039 --- 39
dofetilide antiarrhythmic HERG/HEK IKr 0.0095 --- 94
dofetilide antiarrhythmic HERG/L IKr 0.0095 --- 94
dofetilide antiarrhythmic AT-1 IKr 0.011 --- 129
dofetilide antiarrhythmic AT-1 IKr 0.012 --- 131
dofetilide antiarrhythmic HERG/HEK IKr 0.012 --- 105
dofetilide antiarrhythmic HERG-HEK IKr 0.015 --- 95
dofetilide antiarrhythmic HERG/L IKr 0.015 --- 129
dofetilide antiarrhythmic HERG IKr 0.015 --- 76 at 22°C
dofetilide antiarrhythmic GP VM IKr 0.032 --- 61
dofetilide antiarrhythmic HL-1 IKr 0.047 --- 43
dofetilide antiarrhythmic mouse heart IKr 0.054 --- 81
dofetilide antiarrhythmic HERG/XO IKr 0.125 --- 80
dofetilide antiarrhythmic GP VM IKs >100
61
dofetilide antiarrhythmic HEK-293 IKv1.5 >10
94
doxazosin alpha1-blocker HERG/CHO IKr 2.5 --- 92
E-4031 antiarrhythmic HERG/HEK IKr 0.0077 --- 137
E-4031 antiarrhythmic ferret heart IKr 0.0103 --- 83
E-4031 antiarrhythmic HERG/XO IKr 0.38 --- 2 +MiRP1
E-4031 antiarrhythmic GP VM IKr 0.397 --- 103
E-4031 antiarrhythmic GP VM IKr <5 --- 99
E-4031 antiarrhythmic HERG/XO IKr 0.588 --- 116
E-4031 antiarrhythmic HERG/XO IKr 1.25 --- 2 WT
E-4031 antiarrhythmic HERG/XO IKr 1.4 --- 34 different lab
ebastine antihistamine GP LM H1 0.27 1.9 74
ebastine antihistamine rat VM IK1 >3
75
ebastine antihistamine guinea-pig VM IKr 0.14 --- 75
ebastine antihistamine guinea-pig VM IKs 2
75
ebastine antihistamine
IKv1.5 >1
20 1uM = IC6.5
ebastine antihistamine rat VM Ito >3
75
EDDP opiate HERG/HEK IKr >50 --- 71 methadone metabolite
encainide antiarrhythmic feline VM IKr 6 --- 55
epinastine antihistamine HERG/XO IKr >100 --- 40
erythromycin antibiotic/macrolide AT-1 IKr 54.6 --- 127
erythromycin antibiotic/macrolide GP VM IKr >100 --- 47
erythromycin antibiotic/macrolide
IKr 387 --- 76 at 32-37°C
erythromycin antibiotic/macrolide
Ito 606
76 at 32-37°C
erythromycin antibiotic/macrolide S. pneumoniae MIC 1.36 <0.014 68
fentanyl opiate HERG/HEK IKr 1.8 --- 71
fexofenadine antihistamine GP LM H1 0.26 0.024 74
fexofenadine antihistamine feline VM IKr >5 --- 126
fexofenadine antihistamine
IKr >10
96
fexofenadine antihistamine HERG IKr 13.1 --- 76 at 32-37°C
fexofenadine antihistamine HERG/HEK IKr 21.57 --- 46 at 37°C
fexofenadine antihistamine HERG/XO IKr >500 --- 100
fexofenadine antihistamine
IKs 20.4
76 at 32-37°C
fexofenadine antihistamine
IKv1.5 >50
128
fexofenadine antihistamine feline VM IKv1.5 214
96
fexofenadine antihistamine
IKv1.5 389
76 at 32-37°C
fexofenadine antihistamine XO IKv1.5 >500
100
fexofenadine antihistamine
Ito 112
76 at 32-37°C
flecainide antiarrhythmic feline VM IKr 2.2 --- 55
gatifloxacin antibiotic/quinolone AT-1 IKr 26.5 --- 4
gatifloxacin antibiotic/quinolone HERG/CHO IKr 130 --- 66
glibenclamide sulfonylurea neuroblastoma IKr 74.8 --- 99
glibenclamide sulfonylurea GP VM IKr <100 --- 99
grepafloxacin antibiotic/quinolone AT-1 IKr 27.2 --- 4
grepafloxacin antibiotic/quinolone HERG/CHO IKr 27.5 --- 33 -40 mV
grepafloxacin antibiotic/quinolone HERG/CHO IKr 50 --- 66
haloperidol antipsychotic human AM IK1 >100
46
haloperidol antipsychotic HERG/HEK IKr 0.0281 --- 46 at 37°C
haloperidol antipsychotic HERG/XO IKr 1 --- 108
haloperidol antipsychotic human AM INa 14.4
46
haloperidol antipsychotic human AM Isus 10-100
46
haloperidol antipsychotic human AM Ito 10-100
46
hesperetin flavonoid HERG/XO IKr 288.8 --- 139
ibutilide antiarrhythmic HERG/L IKr 0.015 --- 129
ibutilide antiarrhythmic AT-1 IKr 0.02 --- 131
imipramine antidepressant HERG/CHO IKr 3.4 --- 112
indapamide diuretic GP VM IKs 196
117
ketanserin serotonin antagonist guinea-pig VM IKr >32 --- 79
ketanserin serotonin antagonist rabbit VM Ito 2.25
78
ketoconazole antifungal feline VM IKr 2.5 --- 41
ketoconazole antifungal HERG/XO IKr 49 --- 51
ketoconazole antifungal XO IKv1.5 107
51
ketoconazole antifungal feline VM Ito 10
41
LAAM opiate HERG/HEK IKr 2.2 --- 71
levofloxacin antibiotic/quinolone HERG/CHO IKr 915 --- 66
lopinavir antiviral HERG/HEK IKr 8.6 --- 5
loratidine antihistamine GP cerebellum H1 1 0.3 27
loratidine antihistamine HERG/HEK IK1 >1
45
loratidine antihistamine rat VM IK1 >10
50
loratidine antihistamine HERG/HEK IKr 0.173 --- 45
loratidine antihistamine
IKr >1 --- 50 1uM = IC5
loratidine antihistamine HERG/XO IKr 100 --- 111
loratidine antihistamine
IKs <10
50 10uM = IC58
loratidine antihistamine guinea-pig VM IKs <25
50
loratidine antihistamine HEK 293 IKv1.5 0.8
77
loratidine antihistamine
IKv1.5 1.2
19
loratidine antihistamine HERG/HEK Isus >1
45
loratidine antihistamine HERG/HEK Ito >1
45
loratidine antihistamine rat VM Ito 2.6
50
loratidine antihistamine
Ito >10
50 10uM = IC12
DC-loratidine antihistamine HERG/HEK IKr 1.82 --- 46 at 37°C
LY97241 antiarrhythmic HERG/XO IKr 0.15 --- 109
meperidine opiate HERG/HEK IKr 75 --- 71
methadone opiate HERG/HEK IKr 9.8 --- 71
methadone opiate HERG/HEK IKr 10 --- 70
mexiletine antiarrhythmic rat VM ICaL 5.8 --- 93
mibefradil calcium antagonist guinea pig ICaL 0.2
52 -50 mV
mibefradil calcium antagonist guinea pig ICaL 12
52 -80 mV
mibefradil calcium antagonist
ICaL 18.6
88
mibefradil calcium antagonist
ICaT 2.7
88
mibefradil calcium antagonist AT-1 IKr 0.4-0.8 --- 130
mibefradil calcium antagonist AT-1 IKr 0.75 --- 98
mibefradil calcium antagonist HERG/COS IKr 1.43 --- 42
mibefradil calcium antagonist IKs/COS IKs 11.8
42
mizolastine antihistamine HERG/HEK IKr 0.441 --- 46 at 37°C
MK-499 antiarrhythmic HERG/XO IKr 0.123 --- 106
MK-499 antiarrhythmic guinea-pig VM IKr 0.4 --- 54
morin flavonoid HERG/XO IKr 111.4 --- 139
morphine opiate HERG/HEK IKr > 1000 --- 71
moxifloxacin antibiotic/quinolone AT-1 IKr 0.75 --- 4
moxifloxacin antibiotic/quinolone HERG/CHO IKr 1 --- 97 -40 mV
moxifloxacin antibiotic/quinolone HERG/CHO IKr 41.2 --- 33 -40 mV
moxifloxacin antibiotic/quinolone HERG/CHO IKr 129 --- 66
naringenin flavonoid HERK/HEK IKr 36.5 --- 139 13.8% @ 1 uM
naringenin flavonoid HERG/XO IKr 102.3 --- 139
nelfinavir antiviral HERG/HEK IKr 11.5 --- 5
nifedipine dihydropyridine HERG/HEK IKr >50 --- 136
nitrendipine dihydropyridine HERG/COS IKr >10 --- 42
nitrendipine dihydropyridine IKs/COS IKs >10
42
nitrendipine dihydropyridine rat VM INa 3
133
ofloxacin antibiotic/quinolone HERG/CHO IKr 1420 --- 66
olanzipine antipsychotic human AM IK1 >>100
46
olanzipine antipsychotic HERG/HEK IKr 0.181 --- 46 at 37°C
olanzipine antipsychotic human AM INa >100
46
olanzipine antipsychotic human AM Isus >100
46
olanzipine antipsychotic human AM Ito >100
46
OPC-18790 inotrope AT-1 IKr 0.96 --- 129
perhexiline antianginal HERG/CHO IKr 7.8 --- 124
pimozide antipsychotic rat brain 5HT2 0.031 1.7 44
pimozide antipsychotic human AM IK1 >100
46
pimozide antipsychotic HERG IKr 0.018 --- 65
pimozide antipsychotic HERG/HEK IKr 0.0497 --- 46 at 37°C
pimozide antipsychotic HERG IKs >10
65
pimozide antipsychotic HERG IKv1.5 >10
65
pimozide antipsychotic human AM INa 21.9
46
pimozide antipsychotic human AM Isus >>100
46
pimozide antipsychotic human AM Ito >>100
46
prazosin alpha1-blocker HERG/CHO IKr 3.4 --- 92
procainamide antiarrhythmic AT-1 IKr 380 --- 130
N-acetylprocainamide antiarrhythmic AT-1 IKr 92 --- 98
propranolol beta blocker AT-1 IKr 15 --- 127
pyrilamine antihistamine GP cerebellum H1 0.006 0.005 27
pyrilamine antihistamine
IK1 >10
101 10uM = IC1.3
pyrilamine antihistamine guinea-pig VM IKr 1.1 --- 102
pyrilamine antihistamine
IKr 1.1 --- 101
pyrilamine antihistamine
IKs >10
101 10uM = IC16
quinidine antiarrhythmic feline VM IKr 0.18 --- 126
quinidine antiarrhythmic HERG/L IKr 0.3 --- 130
quinidine antiarrhythmic AT-1 IKr 1 --- 130
quinidine antiarrhythmic HERG/XO IKr 8 --- 80
ranolazine antianginal canine VM ICaL(late) 50 4.2 6
ranolazine antianginal canine VM ICaL(peak) 296 49 6
ranolazine antianginal canine VM IK1 >100
140
ranolazine antianginal canine VM IKr 11.5 --- 140
ranolazine antianginal canine VM IKr 12 --- 6
ranolazine antianginal canine VM IKs 13.4
140
ranolazine antianginal canine VM IKs >> 30 >> 5 6 17% at 30 uM
ranolazine antianginal canine VM INa 21
140
ranolazine antianginal canine VM INa(late) 6 0.5 6
ranolazine antianginal canine VM INaCa 91 15 6
ranolazine antianginal canine VM Ito >100 >9 140 17% at 100 uM
risperidone antipsychotic
5HT2 0.00016 0.0004 104
risperidone antipsychotic
D2 0.0033 0.008 104
risperidone antipsychotic human AM IK1 >100
46
risperidone antipsychotic HERG/HEK IKr 0.163 --- 46 at 37°C
risperidone antipsychotic
IKr 0.394 --- 76 at 32-37°C
risperidone antipsychotic
IKs 9.7
76 at 32-37°C
risperidone antipsychotic
IKv1.5 9.5
76 at 32-37°C
risperidone antipsychotic human AM INa 50-100
46
risperidone antipsychotic human AM Isus >100
46
risperidone antipsychotic
Ito 25.5
76 at 32-37°C
risperidone antipsychotic human AM Ito >100
46
ritonavir antiviral HERK/HEK IKr 8.2 --- 5
RP-58866 antiarrhythmic guinea-pig VM IKr 0.02 --- 62
RP-58866 antiarrhythmic HERG/XO IKr 0.2 --- 62
saquinavir antiviral HERG/HEK IKr 15.3 --- 5
sertindole antipsychotic
5HT2 0.00085 0.17 104
sertindole antipsychotic
D2 0.0074 1.5 104
sertindole antipsychotic human AM IK1 >10
46
sertindole antipsychotic HERG IKr 0.005 --- 76 at 32-37°C
sertindole antipsychotic HERG/HEK IKr 0.0126 --- 46 at 37°C
sertindole antipsychotic HERG/L IKr 0.014 --- 94
sertindole antipsychotic
IKs 0.88
76 at 32-37°C
sertindole antipsychotic HEK IKv1.5 2.12
94
sertindole antipsychotic
IKv1.5 4
76 at 32-37°C
sertindole antipsychotic human AM INa >10
46
sertindole antipsychotic human AM Isus >10
46
sertindole antipsychotic
Ito 8.8
76 at 32-37°C
sertindole antipsychotic human AM Ito >10
46
sildenafil PDE inhibitor HERG/HEK IKr 100 --- 56
sildenafil PDE inhibitor PDE5 PDE5 0.001 0.00001 118
d-sotalol antiarrhythmic GP VM IKr 100 --- 103
d-sotalol antiarrhythmic human AM IKv1.5 >500 --- 53
d-sotalol antiarrhythmic human AM Ito >500
53
sparfloxacin antibiotic/quinolone AT-1 IKr 0.23 --- 4
sparfloxacin antibiotic/quinolone HERG/CHO IKr 13.5 --- 33 -40 mV
sparfloxacin antibiotic/quinolone HERG/CHO IKr 18 --- 66
spironolactone aldosterone antagonist HERG/CHO IKr 23 --- 35
tamoxifen antiestrogen rabbit VM IKr 1 --- 84
tamsulosin alpha1-blocker HERG/CHO IKr 104.8 --- 92
terazosin alpha1-blocker HERG/CHO IKr 21.4 --- 92
terfenadine antihistamine GP cerebellum H1 0.45 9 27
terfenadine antihistamine GP LM H1 0.56 3.7 74
terfenadine antihistamine guinea-pig VM ICa <3
90
terfenadine antihistamine rat VM ICaL 0.14
82
terfenadine antihistamine HERG/HEK IK1 >1
45
terfenadine antihistamine
IK1 >10
31
terfenadine antihistamine guinea-pig VM IK1 >10
31
terfenadine antihistamine guinea-pig VM IKr 0.05 --- 101
terfenadine antihistamine HERG/HEK IKr 0.056 --- 95
terfenadine antihistamine HERG IKr 0.056 --- 76 at 32-37°C
terfenadine antihistamine rabbit VM IKr 0.096 --- 37
terfenadine antihistamine AT-1 IKr 0.097 --- 127
terfenadine antihistamine feline VM IKr 0.15 --- 126
terfenadine antihistamine HERG/HEK IKr 0.204 --- 45
terfenadine antihistamine HERG/XO IKr 0.246 --- 110
terfenadine antihistamine HERG/XO IKr 0.431 --- 40
terfenadine antihistamine HERG/XO IKr 0.48 --- 111
terfenadine antihistamine
IKs 4.4
76 at 32-37°C
terfenadine antihistamine
IKs <10
101 10uM = IC58
terfenadine antihistamine XO IKs 29
110
terfenadine antihistamine XO IKv1.1 34
110
terfenadine antihistamine
IKv1.5 0.367
76 at 32-37°C
terfenadine antihistamine feline VM IKv1.5 0.37
96
terfenadine antihistamine XO IKv1.5 1
128
terfenadine antihistamine
IKv1.5 1.1
18
terfenadine antihistamine XO IKv1.5 2.6
100
terfenadine antihistamine guinea-pig VM INa <3
90
terfenadine antihistamine XO IRK1 23
110
terfenadine antihistamine HERG/HEK Isus >1
45
terfenadine antihistamine guinea-pig VM Ito >1
31
terfenadine antihistamine HERG/HEK Ito >1
45
terfenadine antihistamine
Ito >1
30 1uM = IC11
terfenadine antihistamine
Ito 2.7
76 at 32-37°C
terikalant antiarrhythmic guinea-pig VM IKr 0.031 --- 62
terikalant antiarrhythmic HERG/XO IKr 0.25 --- 62
terodiline antispasmodic AT-1 IKr 0.0037 --- 127
terodiline antispasmodic guinea-pig VM IKr 0.7 --- 60
thioridazine antipsychotic human AM IK1 >100
46
thioridazine antipsychotic HERG/HEK IKr 0.0357 --- 46 at 37°C
thioridazine antipsychotic HERG/CHO IKr 1.07 --- 114
thioridazine antipsychotic HERG/tsA-201 IKr 1.25 --- 49
thioridazine antipsychotic guinea-pig VM IKr 1.25 --- 49
thioridazine antipsychotic guinea-pig VM IKs 14
49
thioridazine antipsychotic human AM INa 7.0
46
thioridazine antipsychotic human AM Isus >100
46
thioridazine antipsychotic human AM Ito 27
46
trimethaphan antihypertensive AT-1 IKr 10 --- 127
valproic acid antiepileptic AT-1 IKr 20 --- 127
verapamil calcium antagonist guinea pig ICaL 0.7
52
verapamil calcium antagonist HERG/HEK IKr 0.143 --- 136
verapamil calcium antagonist HERG/L IKr 0.34 --- 129
verapamil calcium antagonist AT-1 IKr 0.3-1 --- 130
verapamil calcium antagonist HERG/COS IKr 0.83 --- 42
verapamil calcium antagonist AT-1 IKr 1.3 --- 98
verapamil calcium antagonist HERG/XO IKr 3.8 --- 122
verapamil calcium antagonist IKs/COS IKs >10
42
vesnarinone PDE inhibitor rabbit VM IKr 5.7 --- 115
vesnarinone PDE inhibitor human heart PDE3 6.2 1.1 87
WAY-123,398 antiarrhythmic feline VM IKr 0.019 --- 107
ziprasidone antipsychotic human AM IK1 >10
46
ziprasidone antipsychotic HERG/HEK IKr 0.152 --- 46 at 37°C
ziprasidone antipsychotic human AM INa >10
46
ziprasidone antipsychotic human AM Isus >10
46
ziprasidone antipsychotic human AM Ito >10
46
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